Hepatocytes display an eosinophilic cytoplasm

Within this meshwork, the sinusoids lead the flux blood of the hepatic artery and portal vein into the "labrinthus hepatis" (2:1011). In addition to plates and sinusoids, this labyrinth also contains bile canaliculi (1:xxiv). These canaliculi ar about 1 micrometer in diameter; their walls ar made up of adjacent hepatocytes. Together they form a kind of chickenwirelike network inside the hepatocyte plates. The bile canaliculi atomic morsel 18 the primary source of bile released into the duodenum.

These canaliculi atomic number 18 separated from the perisinusoidal and sinusoidal areas by junctional complexes of tight junctions and desmosomes. Hepatocyte gap junctions are generally considered impermeable. They do, however, allow for some communication between live cells.

When viewed under the light microscope, hepatocytes are found to contain large, ordinarily spherical nuclei of varying sizes. In addition, binucleate hepatocytes may be seen as well.

In the adult liver, hepatocytes can be mononucleate, binucleate, and multinucleate. Moreover, these nuclei overstep into different size classes; the classes correspondingly tend to occur in specific ratios

Other hepatocyte organelles piss also been quantitatively analyzed in a number of studies (1:xxix). For example, there are about 2,000 mitochondria per hepatocyte. These account for about 18% of the total cellular volume.

In addition, about 7% of the cellular space is occupied by rough endoplasmic reticulum; reflect endoplasmic reticulum and the Golgi apparatus account for 12% of each hepatocyte. Finally, the hepatocyte's germ plasm membrane consists of a 7 nanometer thick bilayer. This membrane has been found to contain a relatively high fall of glycosylated protein and lipids, as well as a complex ruler of polypeptides (1:xxix).

Following endocytosis, material is transferred to lysosomes and the Golgi zone. Transcytoplasmic transport occurs through use of the hepatocyte's cytoskeleton. It is in the Golgi apparatus that certain substrates undergo oxidation; it is also during this metabolic stage that other materials may be recycled. For example, receptor components may be transferred back to the plasma membrane. In addition, other substances, such as immunoglobulin A, might be packaged into coat or noncoated vesicles and secreted into the

1. Arias, Irwin M.;
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