Commentary
whizz nucleotide polymorphisms and breast cancer: not yet a
succeeder story
Rulla M Tamimi
Channing Laboratory, surgical incision of Medicine, Brigham and Womens Hospital and Harvard Medical School, and De disassemblement of Epidemiology,
Harvard School of Public Health, Boston, Massachusetts, USA
Corresponding author: Rulla Tamimi, rulla.tamimi@channing.harvard.edu
Published: 27 July 2006
This article is online at http://breast-cancer-research.com/content/8/4/108
© 2006 BioMed Central Ltd
Breast Cancer Research 2006, 8:108 (doi:10.1186/bcr1529)
Abstract
chromosomal mutation and its impact on breast cancer systematically.
Numerous studies study examined first base penetrance
susceptibility polymorphisms in candidate genes, with some
reporting substantive findings. However, for the most part these
associations could not be replicated in later(prenominal) studies,
suggesting that the original observations were due to chance
[5]. In a pooled analysis of 46 association studies examining
polymorphisms in 18 different genes, only iii polymorphisms were significantly associated with breast cancer
[5].
Despite considerable efforts made during the other(prenominal) few
years to study genetic variation and breast cancer, on that point has
been little success in identifying important contributions to
breast cancer. The inadequacy of robust and consistent findings from
single SNP association studies led to the effusion of
haplotype studies, which promised to examine more comprehensively the association between harsh genetic variation
in candidate genes and risk for disease. This latest direction of
research efforts has also been somewhat disappointing.
Numerous studies have examined low penetrance susceptibility
polymorphisms in candidate genes, with some reporting significant
findings. However, for the most part these associations could not
be replicated in subsequent studies, suggesting that the original...If you want to get a full essay, order it on our website: Orderessay
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